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Universidade de Évora

 

Departamento de Química
Universidade do Évora
Rua Romão Ramalho, 59
7000 Évora
Portugal
Tel: + 351 266 745 310
NMR Equipment
  • Bruker Avance III 400 with automatic sample changer (24 places)
Unit Homepage

 

Booking | Scheduling

 

 

Main Research Topics

The groups that use the equipment at the University of Evora, come from the LAQV and Hercules research centres. The main strategy areas at the University of Evora are: Health sciences (biomedical and pharmaceutical), cultural heritage, food science and renewable energy. Most of the team from the LAQV centre are involved in either medicinal chemistry, energy or food science related activities.

LAQV Team

Anthony J. Burke; Paulo Mendes; António Teixeira; Luís Martins; Elisabete Carreiro;Carolina Marques

Hercules Team

António Manuel Pereira

 

Areas of Significance

  1. Medicinal chemistry towards new treatments for Alzheimer’s disease and cancer.
  2. Invention of new sustainable catalytic processes for accessing medicinally important compounds.
  3. Development of new asymmetric catalytic processes leading to single-enantiomer chiral compounds with medicinal properties.
  4. Development of New Multi-Component Reactions (MCR) for accessing medicinally relevant compounds.
  5. Synthesis and characterisation of novel optoelectronic molecules for use in optoelectronic devices.
  6. Development of immobilized organocatalysts.
  7. Development of novel NMR techniques for discrimination of olive oil varieties.
  8. Development of novel “smart” and stimuli responsive Molecularly Imprinted Polymers (MIPs) for use in food safety.
  9. Characterisation of Chitosan based nano-particles for veterinary medicine applications.
  10. Thermodynamics and thermophysical properties as well as modelling and molecular simulations of systems with different degrees of complexity (from simple fluids to oil models or lipid bilayers).
  11. Coumarin Probes for Bio-imaging in the context of art restoration.

 

Selected Publications (2016 – 2021)

  1. The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules, P. Brandão, C. Marques, A.J. Burke, Marta Pineiro, Eur. J. Med. Chem. 2021, 211, 113102 (1-48).
  2. Seeking a Fast Screening Method of the Varietal Origin of Olive Oil: The Usefulness of an NMR-Based Approach, Maria João Cabrita, Arona Pires, Anthony J. Burke, Raquel Garcia, Foods. 2021, 10, 399 (1-9).
  3. Multicomponent reactions – a valuable tool for drug discovery and production, P. Brandão, A.J.Burke, M. Pineiro, Química, Bulletin of the Portugese Chemical Society, 2020, 44, 264-276
  4. Novel 1,2,3-triazole epiCinchonas: Transitioning from Organocatalysis to Biological Activities, P. Barrulas, E.P. Carreiro, L. Veiros, A.C. Amorim, J. Gut, P. Rosental, Ó. Lopez, Adrián Puerta, J.M. Padrón, J.G. Fernández-Bolaños, A.J. Burke, Synth. Communications, 2021, 51, 2954-2974.
  5. Recent advances in asymmetric hydrogenation catalysis utilising spiro and other rigid C-stereogenic phosphine ligands, Gesine Hermann, Anthony J. Burke, Hans-Jürgen Federsel, J. Org. Chem. 2021, Perspective article, in press.
  6. Petasis adducts of tryptanthrin – synthesis, biological activity evaluation and druglikeness assessment, Pedro Brandão, Carolina Marques, Eugénia Pinto, Marta Pineiro, Anthony J. Burke, New J. Chem. 2021, 45, 14633-14649.
  7. Ugi reaction synthesis of oxindole-lactam hybrids as selective butyrylcholinesterase inhibitors, Brandão, Pedro; López, Óscar; Leitzbach, Luisa; Stark, Holger; Fernández-Bolaños, José; Burke, Anthony; Pineiro, Marta ACS Med. Chem. Lett. 2021, 12, 1718-1725.
  8. Ugi adducts of isatin as promising antiproliferative agents with druglike properties, Pedro Brandão, Adrián Puerta, José M. Padrón, Maxim Kuznetsov, Anthony J. Burke, Marta Pineiro, Asian Journal Org. Chem. 2021, 10, 1-23.
  9. Synthesis of novel pyrazolo[3,4-b]quinolinebisphosphonic acids and an unexpected intramolecular cyclization and phosphonylation reaction, Fátima C. Teixeira, Carla Lucas, M. João M. Curto, Vânia André, M. Teresa Duarte, António P. S. Teixeira, Org. Biomol. Chem., 2021, 19, 2533–2545.
  10. New modified Nafion-bisphosphonic acidcomposite membranes for enhanced protonconductivity and PEMFC performance, Fatima C. Teixeira, Ana I. de Sa, Antonio P.S. Teixeira, V.M. Ortiz-Martı ́nezc, A. Ortizc, I. Ortizc, C.M. Rangel, Int. J. Hyd. Ener., 2021, 46, 17562-17571.
  11. Chemometric Discrimination of the Varietal Origin of Extra Virgin Olive Oils: Usefulness of C-13 Distortionless Enhancement by Polarization Transfer Pulse Sequence and H-1 Nuclear Magnetic Resonance Data and Effectiveness of Fusion with Mid-Infrared Spectroscopy Data, Malechaux, A , Garcia, R., Dreau, Y.L., Pires, A.,  Dupuy, N., Cabrita, M.J. J. Agri. Food Chem., 2021, 69, 4177-4190.
  12. N-1,2,3-Triazole-Isatin Derivatives for Cholinesterase and -Amyloid Aggregation Inhibition: A Comprehensive Bioassay Study, Carolina S. Marques, Óscar López, Donatella Bagetta, Elisabete P. Carreiro, Sabrina Petralla, Manuela Bartolini, Matthias Hoffmann, Stefano Alcaro, Barbara Monti, Maria Laura Bolognesi, Michael Decker, José G. Fernández-Bolaños and Anthony J. Burke, Bioorganic Chem. 2020, 98, 103753 (1-13).
  13. Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines, Cláudia C. Alves, Carla Grosso, Pedro Barrulas, Ana L. Cardoso, Anthony J. Burke, Américo Lemos, Teresa M. V. D. Pinho e Melo, Synlett, 2020, 31, 553-558.
  14. Synthesis of Novel 1,2,3-Triazole-Dihyropyrimidinone Hybrids using Multicomponent 1,3-Dipolar Cycloaddition(Click)-Biginelli Reactions, Elisabete Carreiro, Ana Sena, José Padrón, Anthony J. Burke, Synlett. 2020, 31, 615-621.
  15. Accessing new 5-α-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction, C.S. Marques, P. McArdle, A. Erxleben, A.J.Burke, Eur. J. Org. Chem. 2020, 3622-3632.
  16. Ambipolar Pentacyclic Diamides with Interesting Electrochemical and Optoelectronic Properties, Carolina S. Marques, Hugo Cruz, Simon E. Lawrence, Sandra Gago, João P. Prates Ramalho, Luís C. Branco, Anthony J. Burke, ChemComm. 2020, 14893 – 14896.
  17. Preaggregation of Asphaltenes in the Presence of Natural Polymers by Molecular Dynamics Simulation, Lucas G. Celia-Silva, Patrícia B. Vilela, Pedro Morgado, Elizabete F. Lucas, Luís F. G. Martins, Eduardo J. M. Filipe, Energy Fuels 2020, 34, 2, 1581–1591.
  18. 7-(diethylamino)-4-methyl-3-vinylcoumarin as a new important intermediate to the synthesis of photosensitizers for DSSC and fluorescent labels for biomolecules, S Martins, A Candeias, AT Caldeira, A Pereira Dyes and Pigment., 2020, 174, 108026 (1-7).
  19. 20) Coumarin Amine-Reactive DYE C392STP: an Efficient Building Block to Synthesize Single Labeled Oligonucleotides with Application as Fish Probes, M. González-Pérez, S. Martins, A. Manhita, A. T. Caldeira, A. Pereira, Applied Biochemistry and Microbiology, 2020, 56, 96–105.
  20. From nano-emulsions to phase separation: evidence of nano-segregation in (alkane + perfluoroalkane) mixtures using 129Xe NMR Spectroscopy, Pedro Morgado, Luís F. G. Martins, Eduardo J. M. Filipe, Phys. Chem. Chem. Phys., 2019, 21, 3742—3751.
  21. Nafion phosphonic acid composite membranes for proton exchange membranes fuel cells, Fátima C. Teixeira, Ana I.de Sá, António P.S.Teixeira, C.M.Rangel, Applied Surface Science, 2019, 487, 889-897.
  22. Supramolecular hydrogel based on a sodium deep eutectic solvente, Catarina Florindo, Lucas G. Celia-Silva, Luís F. G. Martins, Luís C. Branco, Isabel M. Marrucho, Supramolecular hydrogel based on a sodium deep eutectic solvent, Chem. Commun., 2018, 54, 7527—7530.
  23. Understanding the interactions of imidazolium-based ionic liquids with cell membrane models, Carlos M. N. Mendonça, Debora T. Balogh, Simone C. Barbosa, Tânia E. Sintra, Sónia P. M. Ventura, Luís F. G. Martins, Pedro Morgado, Eduardo J. M. Filipe, João A. P. Coutinho, Osvaldo N. Oliveira, Jr. Ana Barros-Timmons, Phys. Chem. Chem. Phys., 2018, 20, 29764—29777.
  24. Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′- Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential, Leonor Corte-Real, Ricardo G. Teixeira, Patrícia Gírio, Elisabeta Comsa, Alexis Moreno, Rachad Nasr, Helé ne Baubichon-Cortay, Fernando Avecilla, Fernanda Marques, M. Paula Robalo, Paulo Mendes, Joao P. Prates Ramalho, M. Helena Garcia, Pierre Falson, Andreia Valente, Inorg. Chem. 2018, 57, 4629−463.
  25. Alkane Coiling in Perfluoroalkane Solutions: A New Primitive Solvophobic Effect Pedro Morgado, Ana Rosa Garcia, Luís F. G. Martins, Laura M. Ilharco, Eduardo J. M. Filipe, Langmuir 2017, 33, 11429−1143.
  26. Perfluoropolyethers: Development of an All-Atom Force Field for Molecular Simulations and Validation with New Experimental Vapor Pressures and Liquid Densities Jana E. Black, Goncalo M. C. Silva, ̧ Christoph Klein, Christopher R. Iacovella, Pedro Morgado, Luís F. G. Martins, Eduardo J. M. Filipe, Clare McCabe, J. Phys. Chem. B 2017, 121, 6588−6600.
  27. Liquid Mixtures Involving Hydrogenated and Fluorinated Alcohols: Thermodynamics, Spectroscopy, and Simulation Pedro Morgado, Ana Rosa Garcia, Laura M. Ilharco, Joao Marcos, Martim Anastacio, Luís F. G. Martins, Eduardo J. M. Filipe, J. Phys. Chem. B 2016, 120, 10091−10105.
  28. Adenine as an organocatalyst for the ring-opening polymerization of lactide: scope, mechanism and access to adenine-functionalized polylactide, Guilherme Nogueira, Audrey Favrelle, Marc Bria, João P. Prates Ramalho, Paulo J. Mendes, Andreia Valente, Philippe Zinck, React. Chem. Eng., 2016, 1, 508–520.