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Faculdade de Farmácia
Universidade de Lisboa
Avenida Professor Gama Pinto
1649-003 Lisboa
Portugal
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Tel: +351 217 946 400
Fax: +351 217 946 470
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NMR Equipment
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Unit Homepage |
Main Research Topics
The NMR equipment plays a key role in all chemistry-based research topics developed at the Research Institute for Medicines (iMed.ULisboa). The NMR techniques (1H, 13C, and 2D-NMR experiments) are routinely used for structure elucidation of small molecules obtained either from synthesis or natural sources, kinetic studies to elucidate reaction mechanisms, metabolic studies, including metabolite identification, and for quantification in drug development studies.
Selected Publications
- Pereira JG, António JPM, Mendonça R, Gomes RFA, Afonso CAM. Rediscovering aminal chemistry: copper(II) catalysed formation under mild conditions. Green Chem., 2020, 22, 7484–7490. https://doi:10.1039/d0gc01977a
- Silva MJSA, Faustino H, Coelho J, Pinto MV, Fernandes A, Compañón I, Corzana F, Gasser G, Gois PMP. Efficient amino sulfhydryl stapling on peptides and proteins using bifunctional NHS activated acrylamides. Angew. Chem. Int. Ed. 2021; 60: 10850. https://doi:10.1002/anie.202016936
- Gomes-Alves AG, Duarte M, Cruz T, Castro H, Lopes F, Moreira R, Ressurreição AS, Tomás AM. Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evaluation and mechanistic studies. Antimicrob Agents Chemother 2021; Apr 26:AAC.01513-20. DOI: 10.1128/AAC.01513-20.
- Barcherini V, Almeida J, Lopes E, Wang M, Silva DM, Mori M, Wang S, Saraiva L, Santos MM. Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer. ChemMedChem 2021, 16, 250–258. https://doi.org/10.1002/cmdc.202000522
- Ferreira RJ, Spengler G, Orthaber A, dos Santos DJVA, Ferreira, MJU. Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi. Org Lett 2021; 23: 274–278. https://Doi:10.1021/acs.orglett.0c03647