{"id":2071,"date":"2022-01-24T11:52:48","date_gmt":"2022-01-24T11:52:48","guid":{"rendered":"https:\/\/ptnmr.web.ua.pt\/wp\/?page_id=2071"},"modified":"2022-02-13T18:21:44","modified_gmt":"2022-02-13T18:21:44","slug":"universidade-de-lisboa-fc","status":"publish","type":"page","link":"https:\/\/ptnmr.web.ua.pt\/index.php\/universidade-de-lisboa-fc\/","title":{"rendered":"Universidade de Lisboa – FC"},"content":{"rendered":"

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Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias<\/div>\n
Universidade de Lisboa<\/div>\n
1749-016 Lisboa<\/div>\n
Portugal<\/div>\n<\/td>\n
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Tel: +351 217 500 918<\/div>\n<\/td>\n<\/tr>\n
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NMR Equipment<\/h5>\n
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  • Bruker Avance 400<\/li>\n<\/ul>\n<\/td>\n
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Unit Homepage<\/h5>\n

ULisboa – FC<\/a><\/p>\n

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Booking | Scheduling<\/h5>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Main Research Topics<\/h4>\n

Coordination and organometallic chemistry<\/p>\n

Organometallic, materials chemistry, and catalysis<\/p>\n

Organic and natural products chemistry<\/p>\n

Supramolecular Chemistry<\/p>\n

Forensic chemistry<\/p>\n

\u00a0<\/strong><\/p>\n

Selected Publications<\/strong><\/p>\n

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  1. Jo\u00e3o Lopes, David Alves, T\u00e2nia S. Morais, Paulo J. Costa, M. F\u00e1tima M. Piedade, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia, New copper(I) and heteronuclear copper(I)\u2011ruthenium(II) complexes: synthesis, structural characterization and cytotoxicity, Inorg. Biochem.<\/em> 2017, 168, 68-78. DOI: 10.1016\/j.jinorgbio.2017.01.007<\/li>\n
  2. T\u00e2nia S. Morais, Yann Jousseaume, M. F\u00e1tima M. Piedade, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia, \u201cImportant cytotoxic and cytostatic effects of new copper(I)\u2013phosphane compounds with N,N, N,O and N,S bidentate ligands, Dalton Trans. <\/em>2018, <\/em>47, 7819. DOI: 10.1039\/c8dt01653d<\/li>\n
  3. Moreira, R. Francisco, E. Comsa, S. Duban-Deweer, V. Labas, A. P. Teixeira-Gomes, L. Combes-Soia, F. Marques, A. Matos, A. Favrelle, C. Rousseau, P. Zinck, P. Falson, M. H. Garcia, A. Preto, A. Valente, Polymer “ruthenium-cyclopentadienyl” conjugates – New emerging anti-cancer drugs, Eur<\/em>. J. Med. Chem<\/em>. 2019, 168, 373\u2013384. DOI: 10.1016\/j.ejmech.2019.02.061<\/li>\n
  4. F. Machado, D. Sequeira, F. Marques, M. F. M. Piedade, M. J. Villa de Brito, M. H. Garcia, A. R. Fernandes, T. S. Morais, New copper(i) complexes selective for prostate cancer cells, Dalton Trans.<\/em> 2020, 49, 12273\u201312286. DOI: 10.1039\/d0dt02157a<\/li>\n
  5. F. Machado, M. Machuqueiro, F. Marques, M. P. Robalo, M. F. M. Piedade, M. H. Garcia, J. D. G. Correia, T. S. Morais, Novel \u201cruthenium cyclopentadienyl\u201d\u2013peptide conjugate complexes against human FGFR(+) breast cancer, Dalton Trans<\/em>. 2020, 49, 5974\u20135987. DOI: 10.1039\/d0dt00955e<\/li>\n
  6. G. Teixeira, D. C. Belisario, X. Fontrodona, I. Romero, A. I. Tomaz, M. H. Garcia, C. Riganti, A. Valente, Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds, Inorg. <\/em>Chem. Front<\/em>. 2021,8,1983\u20131996. DOI: 10.1039\/d0qi01344g<\/li>\n
  7. Sequeira, P. V. Baptista, R. Valente, M. F. M. Piedade, M. H. Garcia, T. S. Morais, A. R. Fernandes, Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action, Dalton Trans<\/em>. 2021, 50, 1845\u20131865. DOI: 10.1039\/d0dt03566a<\/li>\n
  8. Woods, R. D. M. Silva, C. Schmidt, D. Wragg, M. Cavaco, V. Neves, V. F. C. Ferreira, L. Gano, T. S. Morais, F. Mendes, J. D. G. Correia, A. Casini, Bioconjugate Supramolecular Pd2+<\/sup> Metallacages Penetrate the Blood Brain Barrier in Vitro and in Vivo, Bioconjugate Chem<\/em>. 2021, 32, 1399\u22121408. DOI: 10.1021\/acs.bioconjchem.0c00659<\/li>\n
  9. Gimenez, C. D. Nunes, P. D. Vaz, A. A. Valente, P. Ferreira, M. J. Calhorda, Heptacoordinate halocarbonyl molybdenum(II) and tungsten(II) complexes as heterogeneous polymerization catalysts, Journal of Molecular Catalysis A<\/em> 2006, 256, 90-98. https:\/\/doi.org\/10.1016\/j.molcata.2006.04.023<\/a><\/li>\n
  10. Newton L. Dias Filho, Fa\u0301tima C. M. Portugal, J. M. F. Nogueira, P. Branda\u0303o, V. Fe\u0301lix, P. D. Vaz, C. D. Nunes, L. F. Veiros, M. J. Villa de Brito, M. J. Calhorda, An Oligosilsesquioxane Cage Functionalized with Molybdenum(II) Organometallic Fragments, Organometallics<\/em> 2012, 4495\u20134503. DOI: 10.1021\/om3003043<\/li>\n
  11. I. Fernandes, M. S. Saraiva, T. G. Nunes, P. D. Vaz, C. D. Nunes, Highly enantioselective olefin epoxidation controlled by helical confined environments, J. Catal.<\/em> 2014, 309, 21-32. DOI: 10.1016\/j.jcat.2013.08.032<\/li>\n
  12. Vasconcellos-Dias, J. Marreiros, R. Sales, V. F\u00e9lix, P. Brand\u00e3o, C. D. Nunes, M. J. Calhorda, New molybdenum(II) complexes with a-diimine ligands: synthesis, structure, and catalytic activity in olefin epoxidation, Molecules<\/em> 2019, 24, 578.<\/li>\n
  13. I. Vicente, X. Wu, Y. Ortin, L. P. Ferreira, M. D. Carvalho, S. Realista, A. Barker, G. G. Morgan, N. Galamba, P. J. Costa, M. J. Calhorda, P. N. Martinho, \u201cDirecting self-assembly in solution towards improved cooperativity in Fe(III) complexes with amphiphilic tridentate ligands\u201d, Dalton<\/em> Trans.<\/em> 2019,\u00a048<\/em>, 4239-4247. DOI: 10.1039\/C9DT00032A.<\/li>\n
  14. N. Martinho, Ana I. Vicente, Sara Realista, Marta S. Saraiva, Ana Melato, Liliana P. Ferreira, Maria de Deus Carvalho, “Solution and solid state properties of Fe(III) complexes bearing N-ethyl-N-(2-aminoethyl)salicylaldiminate ligands”, J. Organomet. <\/em>Chem.<\/em> 2014, 760<\/em>, 48-54. DOI: 10.1016\/j.jorganchem.2013.12.028.<\/li>\n
  15. Realista, J. C. Almeida, S. A. Milheiro, N. A. G. Bandeira, L. G. Alves, F. Madeira, M. J. Calhorda, P. N. Martinho, \u201cCo(II) cryptates convert CO2<\/sub> into CO and CH4<\/sub> under visible light\u201d, Chem. Eur. J.<\/em> 2019, 25<\/em>,11670\u201311679 (hot paper). DOI: 10.1002\/chem.201901806.<\/li>\n
  16. Fortuna, P. J. Costa, M. F. M. Piedade, M. C. Oliveira, N. M. Xavier “Synthesis of triazole\u2010containing furanosyl nucleoside analogs and their phosphate, phosphoramidate or phoshonate derivatives as potential sugar diphosphate or nucleotide mimetics\u201d, ChemPlusChem<\/em> 2020, 85<\/em>, 1676\u20111691. DOI: 10.1002\/cplu.202000424.<\/li>\n
  17. M. Xavier, E. C. de Sousa, M. P. Pereira, A. Loesche, I. Serbian, R. Csuk, M. C. Oliveira, \u201cSynthesis and biological evaluation of structurally varied 5\u02b9-\/6\u02b9-isonucleosides and theobromine-containing N<\/em>-isonucleosidyl derivatives\u201d, Pharmaceuticals<\/em> 2019, 12(3), 103. DOI: 10.3390\/ph12030103.<\/li>\n
  18. M. Xavier, A. Porcheron, D. Batista, R. Jorda, E. \u0158ezn\u00ed\u010dkov\u00e1, V. Kry\u0161tof, M. C. Oliveira, \u201cExploitation of new structurally diverse D-glucuronamide-containing N<\/em>-glycosyl compounds: synthesis and anticancer potential, Org. Biomol. Chem.<\/em> 2017, 15, 4667-4680. DOI: 10.1039\/C7OB00472A.<\/li>\n
  19. M. de Matos, M. T. Bl\u00e1zquez-S\u00e1nchez, C. Sousa, M. C. Oliveira, R. F. M. de Almeida, A. P. Rauter, Almeida, A. P. Rauter, C-Glucosylation as a tool for the prevention of PAINS-induced membrane dipole potential alterations. Sci. Rep.<\/em> 2021, 11, 4443.<\/li>\n
  20. D. Grayson, M. P. Baumgartner, C. S. Souza, S. J. Dawes, I. G. El Idrissi, J. C. Louth, S. Stimpson, E. Mead, C. Dunbar, J. Wolak, G. Sharman, D. Evans, A. Zhuravleva, M. S. Roldan, N. A. Colabufo, K. Ning, C. Garwood, J. A. Thomas, B. M. Partridge, A. V. Leon, V. J. Gillet, A. P. Rauter, B. Chen, Amyloid binding and beyond: a new approach for Alzheimer’s disease drug discovery targeting Abo\u2013PrPC<\/sup> binding and downstream pathways, Chem. Sci<\/em>. 2021, 12, 3768-2785 (Edge Article).<\/li>\n
  21. M. Matos, M. T. Bl\u00e1zquez-S\u00e1nchez, A. Bento-Oliveira, R. F. M. de Almeida, R. Nunes, P. E. M. Lopes, M. Machuqueiro, J. S. Crist\u00f3v\u00e3o, C. M. Gomes, C. S. Souza, I. G. El Idrissi, N. A. Colabufo, A. Diniz, F. Marcelo, M. C. Oliveira, O. L\u00f3pez, J. G. Fernandez-Bola\u00f1os, P. D\u00e4twyler, B. Ernst, K. Ning, C. Garewood, B. Chen, A. P. Rauter, Glucosylpolyphenols as Inhibitors of A\u03b2-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer\u2019s Disease, J. Med. Chem<\/em>. 2020, 63 (20) 11663\u201311690.<\/li>\n
  22. M. Matos, A. Martins, T. Man, D. Evans, M. Walter, M. C. Oliveira, O. Lopez, J. G. Fernandez-Bola\u00f1os, P. Datwyler, B. Ernst, M. P. Macedo, M. Contino, N. A. Colabufo, A. P. Rauter, Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Abeta(1-42)-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells, Pharmaceuticals<\/em> 2019, 12(2), 98.<\/li>\n
  23. Dias, A. Martins, A. Pelerito, M. C. Oliveira, M. Contino, N. A. Colabufo, A. P. Rauter, Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis<\/em>, Eur. J. Org. Chem<\/em>. 2019, 12, 2224 \u2013 2233.<\/li>\n
  24. M. Matos, T. Man, I. Idrissi, C. C. Souza, E. Mead, C. Dunbar, J. Wolak, M. C. Oliveira, D. Evans, J. Grayson, B. Partridge, C. Garwood, K. Ning, G. Sharman, B. Chen, A. P. Rauter, Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer\u2019s disease: synthesis, binding affinity towards amyloid \u03b2 oligomers (A\u03b2o) and ability to disrupt A\u03b2o-PrPC interactions, Pure Appl. Chem.<\/em> 2019, 91(7), 1107-1136.<\/li>\n
  25. Dias, A. M. Matos, M. T. Bl\u00e1squez-S\u00e1nchez, P. Calado, A. Martins, P. D\u00e4twyler, B. Ernst, M. Paula Macedo, N. Colabufo, A. P. Rauter, 2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature, Pure Appl. <\/em>Chem.<\/em> 2019, 91(7), 1209\u20111221.<\/li>\n
  26. Dias, J. Pais, R. Nunes, M.T. Bl\u00e1zquez-S\u00e1nchez, J. T. Marqu\u00eas, A. F. Almeida, P. Serra, N. M. Xavier, D. Vila-Vi\u00e7osa, M. Machuqueiro, A. S. Viana, A. Martins, M. S. Santos, A. Pelerito, R. Dias, R. Tenreiro, M. C. Oliveira, M. Contino, N. A. Colabufo, R . F. M. de Almeida, A. P. Rauter, Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes, Nat Commun<\/em> 2018, 9, 4857. DOI: 10.1038\/s41467-018-06488-4<\/li>\n
  27. R. Jesus, D. Vila-Vi\u00e7osa, M. Machuqueiro, A. P. Marques, T. M. Dore, A. P. Rauter, Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co\u2011Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation, J. Med. Chem<\/em>. 2017, 60, 568\u2212579.<\/li>\n
  28. M. Matos, J. S. Crist\u00f3v\u00e3o, D. V. Yashunsky, N. E. Nifantiev, A. S. Viana, C. M. Gomes, A. P. Rauter, Synthesis and effects of flavonoid structure variation on amyloid-beta aggregation, Pure Appl. <\/em>Chem<\/em>. 2017, 89(9), 1305-1320.<\/li>\n
  29. Cachatra, A. Almeida, J. Sardinha, S. D. Lucas, A. Gomes, P. D. Vaz, M. H. Florencio, R. Nunes, D. Vila-Vi\u00e7osa, M. J. Calhorda, A. P. Rauter, Wittig Reaction: Domino Olefination and Stereoselectivity DFT Study. Synthesis of the Miharamycins\u2019 Bicyclic Sugar Moiety, Org. Lett<\/em>. 2015, 17(22), 5622-5625.<\/li>\n
  30. Rafael F. A. Gomes, Jo\u00e3o M. J. M. Ravasco, K\u00e9ssia H. S. Andrade, Jaime A. S. Coelho, Rui Moreira, Rafael Oliveira, F\u00e1tima Nogueira, Carlos A. M. Afonso, Tandem Thio-Michael Addition\/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived \u03b4-Lactone-Fused Cyclopentnones, ChemSusChem<\/em> 2022, e202102204. DOI: 1002\/cssc.202102204<\/li>\n
  31. Rafael F. A. Gomes, Jaime A. S. Coelho, Carlos A. M. Afonso; Direct Conversion of Activated 5-Hydroxymethylfurfural into \u03b4-Lactone-fused Cyclopentenones, ChemSusChem<\/em> 2019, 12, 420\u2011425. DOI: 10.1002\/cssc.201802537<\/li>\n
  32. Rafael F. A. Gomes, Nuno R. Esteves, Jaime A. S. Coelho, Carlos A. M. Afonso, Copper(II) triflates as reusable catalyst for the synthesis of trans-4,5-diamino-cyclopent-2-enones in water, Org. Chem<\/em>. 2018, 83, 7509-7513<\/li>\n
  33. Cristina Moiteiro, Igor Marques, William G. Ryder, Vasco Cachatra, S\u00edlvia Carvalho, Li-Jun Chen, Brian J. Goodfellow, Philip Gale, V\u00edtor F\u00e9lix, Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library, J. Org. Chem.<\/em> 2021, e202101484. DOI: 10.1002\/ejoc.202101484<\/li>\n
  34. Paulo Vieira, Margarida Q. Miranda, Igor Marques, S\u00edlvia Carvalho, Li-Jun Chen, Ethan Howe, Carl Zhen, Claudia Y. Leung, Michael J Spooner, B\u00e1rbara Morgado, Odete A. B. Cruz e Silva, Cristina Moiteiro, Philip Gale, V\u00edtor F\u00e9lix, Development of a library of thiophene-based drug\u2011like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity, Eur. J.<\/em> 2020, 26; 889-899.<\/li>\n
  35. Miguel M. Santos, Igor Marques, S\u00edlvia Carvalho, Cristina Moiteiro, V\u00edtor F\u00e9lix, Recognition of bio-relevant dicarboxylate anions by an azacalix[2]arene[2]triazine derivative decorated with urea moieties, Biomol. Chem.<\/em> 2015, 13, 3070\u20133085. DOI: 10.1039\/C4OB02283A<\/li>\n
  36. Jo\u00e3o M. Caio, Teresa Esteves, S\u00edlvia Carvalho, Cristina Moiteiro, Vitor F\u00e9lix, Azacalix[2]arene[2]triazine-based receptors bearing carboxymethyl pendant arms on nitrogen bridges: synthesis and evaluation of their coordination ability towards copper(II), Biomol. Chem<\/em>. 2014, 12, 589-599. DOI: 10.1039\/c3ob42047g<\/li>\n
  37. Ana I. Vicente, Jo\u00e3o M. Caio, Jo\u00e3o Sardinha, Cristina Moiteiro, Rita Delgado, V\u00edtor F\u00e9lix, Evaluation of the binding ability of tetraaza[2]arene[2]triazine receptors anchoring L\u2011alanine units for aromatic carboxylate anions, Tetrahedron<\/em>, 2012, 68, (2), 670-680. DOI: 10.1016\/j.tet.2011.10.090<\/li>\n
  38. Ana Cristina Figueiredo, Cristina Moiteiro, Maria da Concei\u00e7\u00e3o Rodrigues, Ant\u00f3nio de Almeida, Essential oil composition from Cryptomeria japonica D. Don<\/em> grown in Azores. Biomass valorization from forest management, Prod.<\/em> Commun.<\/em> 2021, 16(8), 1-10. https:\/\/doi.org\/10.1177\/1934578×211038431<\/a><\/li>\n
  39. Cristina Moiteiro, Teresa Esteves, Lu\u00eds Ramalho, Rosario Rojas, Sandra Alvarez, Susana Zacchino, Helena Bragan\u00e7a, Essential Oil Characterization of Two Azorean Cryptomeria japonica Populations and Their Biological Evaluations, Prod.<\/em> Commun<\/em> 2013, 8 (12), 1785\u20111790. https:\/\/doi.org\/10.1177\/1934578X1300801233<\/a><\/li>\n
  40. Silva, C. Alves, S. Pinteus, P. Susano, M. Sim\u00f5es, M. Guedes, A. Martins, S. Rehfeldt, H. Gaspar, M. Goetter, A. Alfonso, R. Pedrosa, Disclosing the potential of Eleganolone for Parkinson\u2019s Disease therapeutics: Neuroprotective and anti-inflammatory activities, Pharmacol. Res. <\/em>2021, 168, 105589. doi.org\/10.1016\/j.phrs.2021.105589<\/a><\/li>\n
  41. Gaspar, S. Bronze, C. Oliveira, B.L. Victor, M. Machuqueiro, R. Pacheco, M. J. Caldeira, S. Santos, Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones, Forensic Sci. Int.<\/em> 2018, 290, 146-56. doi.org\/10.1016\/j.forsciint.2018.07.001<\/li>\n
  42. Gaspar, S. Bronze, S. Cir\u00edaco, C. Leal, A. Matias, J. Rodrigues, C. Oliveira, C. Cordeiro, S. Santos, 4F-PBP (4\u2019-fluoro-a-pyrrolidinobutyrophenone), a new substance of abuse: structural characterization and purity NMR profiling, Forensic Sci. Int.<\/em> 2015, 252, 168\u2011176. doi.org\/10.1016\/j.forsciint.2015.05.003<\/li>\n
  43. E. S. Bernardes, M. L. S. Matos Lopes, J. R. Ascenso, M. E. Minas da Piedade, From Molecules to Crystals: The Solvent Plays an Active Role Throughout the Nucleation Pathway of Molecular Organic Crystals, Cryst. Growth Des. 2014, 14, 5436\u20115441. DOI: 10.1021\/cg500609g<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias Universidade de Lisboa 1749-016 Lisboa Portugal Tel: +351 217 500 918 NMR Equipment Bruker Avance 400 Unit Homepage ULisboa – FC   Booking | Scheduling   Main Research Topics Coordination and organometallic chemistry Organometallic, materials chemistry, and catalysis Organic and natural products chemistry Supramolecular Chemistry Forensic… Read More »Universidade de Lisboa – FC<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":""},"_links":{"self":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2071"}],"collection":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/comments?post=2071"}],"version-history":[{"count":10,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2071\/revisions"}],"predecessor-version":[{"id":3133,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2071\/revisions\/3133"}],"wp:attachment":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/media?parent=2071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}