{"id":2299,"date":"2022-01-26T12:05:06","date_gmt":"2022-01-26T12:05:06","guid":{"rendered":"https:\/\/ptnmr.web.ua.pt\/wp\/?page_id=2299"},"modified":"2022-02-15T15:53:58","modified_gmt":"2022-02-15T15:53:58","slug":"universidade-de-evora","status":"publish","type":"page","link":"https:\/\/ptnmr.web.ua.pt\/index.php\/universidade-de-evora\/","title":{"rendered":"Universidade de \u00c9vora"},"content":{"rendered":"

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Departamento de Qu\u00edmica<\/div>\n
Universidade do \u00c9vora<\/div>\n
Rua Rom\u00e3o Ramalho, 59<\/div>\n
7000 \u00c9vora<\/div>\n
Portugal<\/div>\n<\/td>\n
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Tel: + 351 266 745 310<\/div>\n<\/td>\n<\/tr>\n
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NMR Equipment<\/h5>\n
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  • Bruker Avance III 400 with automatic sample changer (24 places)<\/li>\n<\/ul>\n<\/td>\n
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Unit Homepage<\/h5>\n

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Booking | Scheduling<\/h5>\n

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Main Research Topics<\/strong><\/h4>\n

The groups that use the equipment at the University of Evora, come from the LAQV and Hercules research centres. The main strategy areas at the University of Evora are: Health sciences (biomedical and pharmaceutical), cultural heritage, food science and renewable energy. Most of the team from the LAQV centre are involved in either medicinal chemistry, energy or food science related activities.<\/p>\n

LAQV Team<\/strong><\/p>\n

Anthony J. Burke; Paulo Mendes; Ant\u00f3nio Teixeira; Lu\u00eds Martins; Elisabete Carreiro;Carolina Marques<\/p>\n

Hercules Team<\/strong><\/p>\n

Ant\u00f3nio Manuel Pereira<\/p>\n

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Areas of Significance<\/strong><\/p>\n

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  1. Medicinal chemistry towards new treatments for Alzheimer\u2019s disease and cancer.<\/li>\n
  2. Invention of new sustainable catalytic processes for accessing medicinally important compounds.<\/li>\n
  3. Development of new asymmetric catalytic processes leading to single-enantiomer chiral compounds with medicinal properties.<\/li>\n
  4. Development of New Multi-Component Reactions (MCR) for accessing medicinally relevant compounds.<\/li>\n
  5. Synthesis and characterisation of novel optoelectronic molecules for use in optoelectronic devices.<\/li>\n
  6. Development of immobilized organocatalysts.<\/li>\n
  7. Development of novel NMR techniques for discrimination of olive oil varieties.<\/li>\n
  8. Development of novel \u201csmart\u201d and stimuli responsive Molecularly Imprinted Polymers (MIPs) for use in food safety.<\/li>\n
  9. Characterisation of Chitosan based nano-particles for veterinary medicine applications.<\/li>\n
  10. Thermodynamics and thermophysical properties as well as modelling and molecular simulations of systems with different degrees of complexity (from simple fluids to oil models or lipid bilayers).<\/li>\n
  11. Coumarin Probes for Bio-imaging in the context of art restoration.<\/li>\n<\/ol>\n

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    Selected Publications (2016 – 2021)<\/h4>\n
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    1. The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules, P. Brand\u00e3o, C. Marques, A.J. Burke, Marta Pineiro, Eur. J. Med. Chem. 2021, 211, 113102 (1-48).<\/li>\n
    2. Seeking a Fast Screening Method of the Varietal Origin of Olive Oil: The Usefulness of an NMR-Based Approach, Maria Jo\u00e3o Cabrita, Arona Pires, Anthony J. Burke, Raquel Garcia, Foods. 2021, 10, 399 (1-9).<\/li>\n
    3. Multicomponent reactions \u2013 a valuable tool for drug discovery and production, P. Brand\u00e3o, A.J.Burke, M. Pineiro, Qu\u00edmica, Bulletin of the Portugese Chemical Society, 2020, 44, 264-276<\/li>\n
    4. Novel 1,2,3-triazole epiCinchonas: Transitioning from Organocatalysis to Biological Activities, P. Barrulas, E.P. Carreiro, L. Veiros, A.C. Amorim, J. Gut, P. Rosental, \u00d3. Lopez, Adri\u00e1n Puerta, J.M. Padr\u00f3n, J.G. Fern\u00e1ndez-Bola\u00f1os, A.J. Burke, Synth. Communications, 2021, 51, 2954-2974.<\/li>\n
    5. Recent advances in asymmetric hydrogenation catalysis utilising spiro and other rigid C-stereogenic phosphine ligands, Gesine Hermann, Anthony J. Burke, Hans-J\u00fcrgen Federsel, J. Org. Chem. 2021, Perspective article, in press.<\/li>\n
    6. Petasis adducts of tryptanthrin \u2013 synthesis, biological activity evaluation and druglikeness assessment, Pedro Brand\u00e3o, Carolina Marques, Eug\u00e9nia Pinto, Marta Pineiro, Anthony J. Burke, New J. Chem. 2021, 45, 14633-14649.<\/li>\n
    7. Ugi reaction synthesis of oxindole-lactam hybrids as selective butyrylcholinesterase inhibitors, Brand\u00e3o, Pedro; L\u00f3pez, \u00d3scar; Leitzbach, Luisa; Stark, Holger; Fern\u00e1ndez-Bola\u00f1os, Jos\u00e9; Burke, Anthony; Pineiro, Marta ACS Med. Chem. Lett. 2021, 12, 1718-1725.<\/li>\n
    8. Ugi adducts of isatin as promising antiproliferative agents with druglike properties, Pedro Brand\u00e3o, Adri\u00e1n Puerta, Jos\u00e9 M. Padr\u00f3n, Maxim Kuznetsov, Anthony J. Burke, Marta Pineiro, Asian Journal Org. Chem. 2021, 10, 1-23.<\/li>\n
    9. Synthesis of novel pyrazolo[3,4-b]quinolinebisphosphonic acids and an unexpected intramolecular cyclization and phosphonylation reaction, F\u00e1tima C. Teixeira, Carla Lucas, M. Jo\u00e3o M. Curto, V\u00e2nia Andr\u00e9, M. Teresa Duarte, Ant\u00f3nio P. S. Teixeira, Org. Biomol. Chem., 2021, 19, 2533\u20132545.<\/li>\n
    10. New modified Nafion-bisphosphonic acidcomposite membranes for enhanced protonconductivity and PEMFC performance, Fatima C. Teixeira, Ana I. de Sa, Antonio P.S. Teixeira, V.M. Ortiz-Mart\u0131 \u0301nezc, A. Ortizc, I. Ortizc, C.M. Rangel, Int. J. Hyd. Ener., 2021, 46, 17562-17571.<\/li>\n
    11. Chemometric Discrimination of the Varietal Origin of Extra Virgin Olive Oils: Usefulness of C-13 Distortionless Enhancement by Polarization Transfer Pulse Sequence and H-1 Nuclear Magnetic Resonance Data and Effectiveness of Fusion with Mid-Infrared Spectroscopy Data, Malechaux, A , Garcia, R., Dreau, Y.L., Pires, A.,\u00a0 Dupuy, N., Cabrita, M.J. J. Agri. Food Chem., 2021, 69, 4177-4190.<\/li>\n
    12. N-1,2,3-Triazole-Isatin Derivatives for Cholinesterase and \uf062-Amyloid Aggregation Inhibition: A Comprehensive Bioassay Study, Carolina S. Marques, O\u0301scar Lo\u0301pez, Donatella Bagetta, Elisabete P. Carreiro, Sabrina Petralla, Manuela Bartolini, Matthias Hoffmann, Stefano Alcaro, Barbara Monti, Maria Laura Bolognesi, Michael Decker, Jos\u00e9 G. Fern\u00e1ndez-Bola\u00f1os and Anthony J. Burke, Bioorganic Chem. 2020, 98, 103753 (1-13).<\/li>\n
    13. Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines, Cl\u00e1udia C. Alves, Carla Grosso, Pedro Barrulas, Ana L. Cardoso, Anthony J. Burke, Am\u00e9rico Lemos, Teresa M. V. D. Pinho e Melo, Synlett, 2020, 31, 553-558.<\/li>\n
    14. Synthesis of Novel 1,2,3-Triazole-Dihyropyrimidinone Hybrids using Multicomponent 1,3-Dipolar Cycloaddition(Click)-Biginelli Reactions, Elisabete Carreiro, Ana Sena, Jos\u00e9 Padr\u00f3n, Anthony J. Burke, Synlett. 2020, 31, 615-621.<\/li>\n
    15. Accessing new 5-\u03b1-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction, C.S. Marques, P. McArdle, A. Erxleben, A.J.Burke, Eur. J. Org. Chem. 2020, 3622-3632.<\/li>\n
    16. Ambipolar Pentacyclic Diamides with Interesting Electrochemical and Optoelectronic Properties, Carolina S. Marques, Hugo Cruz, Simon E. Lawrence, Sandra Gago, Jo\u00e3o P. Prates Ramalho, Lu\u00eds C. Branco, Anthony J. Burke, ChemComm. 2020, 14893 \u2013 14896.<\/li>\n
    17. Preaggregation of Asphaltenes in the Presence of Natural Polymers by Molecular Dynamics Simulation, Lucas G. Celia-Silva, Patr\u00edcia B. Vilela, Pedro Morgado, Elizabete F. Lucas, Lu\u00eds F. G. Martins, Eduardo J. M. Filipe, Energy Fuels 2020, 34, 2, 1581\u20131591.<\/li>\n
    18. 7-(diethylamino)-4-methyl-3-vinylcoumarin as a new important intermediate to the synthesis of photosensitizers for DSSC and fluorescent labels for biomolecules, S Martins, A Candeias, AT Caldeira, A Pereira Dyes and Pigment., 2020, 174, 108026 (1-7).<\/li>\n
    19. 20) Coumarin Amine-Reactive DYE C392STP: an Efficient Building Block to Synthesize Single Labeled Oligonucleotides with Application as Fish Probes, M. Gonz\u00e1lez-P\u00e9rez, S. Martins, A. Manhita, A. T. Caldeira, A. Pereira, Applied Biochemistry and Microbiology, 2020, 56, 96\u2013105.<\/li>\n
    20. From nano-emulsions to phase separation: evidence of nano-segregation in (alkane + perfluoroalkane) mixtures using 129Xe NMR Spectroscopy, Pedro Morgado, Lu\u00eds F. G. Martins, Eduardo J. M. Filipe, Phys. Chem. Chem. Phys., 2019, 21, 3742\u20143751.<\/li>\n
    21. Nafion phosphonic acid composite membranes for proton exchange membranes fuel cells, F\u00e1tima C. Teixeira, Ana I.de S\u00e1, Ant\u00f3nio P.S.Teixeira, C.M.Rangel, Applied Surface Science, 2019, 487, 889-897.<\/li>\n
    22. Supramolecular hydrogel based on a sodium deep eutectic solvente, Catarina Florindo, Lucas G. Celia-Silva, Lu\u00eds F. G. Martins, Lu\u00eds C. Branco, Isabel M. Marrucho, Supramolecular hydrogel based on a sodium deep eutectic solvent, Chem. Commun., 2018, 54, 7527\u20147530.<\/li>\n
    23. Understanding the interactions of imidazolium-based ionic liquids with cell membrane models, Carlos M. N. Mendon\u00e7a, Debora T. Balogh, Simone C. Barbosa, T\u00e2nia E. Sintra, S\u00f3nia P. M. Ventura, Lu\u00eds F. G. Martins, Pedro Morgado, Eduardo J. M. Filipe, Jo\u00e3o A. P. Coutinho, Osvaldo N. Oliveira, Jr. Ana Barros-Timmons, Phys. Chem. Chem. Phys., 2018, 20, 29764\u201429777.<\/li>\n
    24. Methyl-cyclopentadienyl Ruthenium Compounds with 2,2\u2032- Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential, Leonor Corte-Real, Ricardo G. Teixeira, Patr\u00edcia G\u00edrio, Elisabeta Comsa, Alexis Moreno, Rachad Nasr, Hele\u0301 ne Baubichon-Cortay, Fernando Avecilla, Fernanda Marques, M. Paula Robalo, Paulo Mendes, Joao P. Prates Ramalho, M. Helena Garcia, Pierre Falson, Andreia Valente, Inorg. Chem. 2018, 57, 4629\u2212463.<\/li>\n
    25. Alkane Coiling in Perfluoroalkane Solutions: A New Primitive Solvophobic Effect Pedro Morgado, Ana Rosa Garcia, Lu\u00eds F. G. Martins, Laura M. Ilharco, Eduardo J. M. Filipe, Langmuir 2017, 33, 11429\u22121143.<\/li>\n
    26. Perfluoropolyethers: Development of an All-Atom Force Field for Molecular Simulations and Validation with New Experimental Vapor Pressures and Liquid Densities Jana E. Black, Goncalo M. C. Silva, \u0327 Christoph Klein, Christopher R. Iacovella, Pedro Morgado, Lu\u00eds F. G. Martins, Eduardo J. M. Filipe, Clare McCabe, J. Phys. Chem. B 2017, 121, 6588\u22126600.<\/li>\n
    27. Liquid Mixtures Involving Hydrogenated and Fluorinated Alcohols: Thermodynamics, Spectroscopy, and Simulation Pedro Morgado, Ana Rosa Garcia, Laura M. Ilharco, Joao Marcos, Martim Anastacio, Lu\u00eds F. G. Martins, Eduardo J. M. Filipe, J. Phys. Chem. B 2016, 120, 10091\u221210105.<\/li>\n
    28. Adenine as an organocatalyst for the ring-opening polymerization of lactide: scope, mechanism and access to adenine-functionalized polylactide, Guilherme Nogueira, Audrey Favrelle, Marc Bria, Jo\u00e3o P. Prates Ramalho, Paulo J. Mendes, Andreia Valente, Philippe Zinck, React. Chem. Eng., 2016, 1, 508\u2013520.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

        Departamento de Qu\u00edmica Universidade do \u00c9vora Rua Rom\u00e3o Ramalho, 59 7000 \u00c9vora Portugal Tel: + 351 266 745 310 NMR Equipment Bruker Avance III 400 with automatic sample changer (24 places) Unit Homepage   Booking | Scheduling     Main Research Topics The groups that use the equipment at the University of Evora, come… Read More »Universidade de \u00c9vora<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":""},"_links":{"self":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2299"}],"collection":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/comments?post=2299"}],"version-history":[{"count":13,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2299\/revisions"}],"predecessor-version":[{"id":3259,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/2299\/revisions\/3259"}],"wp:attachment":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/media?parent=2299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}