![\"\"](\"http:\/\/ptnmr.web.ua.pt\/wp\/wp-content\/uploads\/2022\/02\/UPorto_2-300x106.png\")
<\/td>\nNMR Equipment<\/h5>\n\n- Bruker Ascend 600 MHz<\/li>\n
- Bruker Avance III 400 MHz<\/li>\n
- Bruker Ascend III 400 MHz<\/li>\n<\/ul>\n<\/td>\n
\nUnit Homepage<\/h5>\n
UPorto – CEMUP<\/a><\/p>\nBooking | Scheduling<\/h5>\n
lrmn@cemup.up.pt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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Main Research Topics<\/h4>\n\n- Development, acquisition, interpretation and manual-fine tuning of NMR data related, but not limited to: (1) structural characterization of organic and inorganic compounds; (2) compositional profiling of complex mixtures; (3) quality control; (4) quantitative analyses; (5) purity determination; (6) molecular dynamics and kinetic monitoring of reactions;<\/li>\n<\/ul>\n
<\/p>\n
\n- Provide in-house researchers, graduate, post-graduate students and external users with access to know-how, technology, and state-of-the-art infrastructure for the study of biological macromolecules and their complexes in complex media, molecular interactions and ligand recognition events in a wide range of chemical and biochemical systems;<\/li>\n<\/ul>\n
<\/p>\n
\n- Expand the development and application of novel NMR methods to:<\/li>\n<\/ul>\n
\n- \n
\n- Disclosure the molecular mechanisms driving immunoreactive peptide binding, uptake and dynamic behavior on intestinal epithelial membrane models of wheat, milk, peanut and egg-related food intolerances as well as their interaction within the intracellular milieu of disease-relevant cell models, with the purpose of inferring the physiochemical effects imposed by this crowded environment on the structure, dynamics and toxicity of isotopically-labelled proteins and peptides;<\/li>\n
- Unravel the chemistry behind food astringency and bitterness perception, and ways of modulating these organoleptic sensations at the matrix compositional level – part of a recently ERC-funded project entitled \u201cNew Molecular and Cell-based Approaches to assess Food Astringency and Bitterness\u201d; granted to Dra. Susana Soares from LAQV-REQUIMTE;<\/li>\n
- Perform metabolomic profiling of biological fluids (blood, urine and saliva) for a more comprehensive and integrated understanding of the pathways by which diet interacts with the body to affect health and\/or oral physiology at the individual and population level.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n
<\/p>\n
\n- Support the rational design of molecules and (bio)materials with fine-tuned physicochemical properties and of innovative (and cleaner) synthetic routes with enhanced stereoselectivity and applicability in the field of biomedical, agricultural, environmental and food research;<\/li>\n<\/ul>\n
<\/p>\n
\n- Bring synergy towards the use of NMR spectroscopy and computational methods to probe energetics, structural rearrangements, and conformational fluctuations in allosteric systems, for bioengineering, de novo<\/em> protein design and drug discovery purposes.<\/li>\n<\/ul>\n
<\/p>\n
Selected Publications<\/strong><\/h4>\n\n- Figueiredo, Sandra AC, et al.<\/em> “Discovery of Cyanobacterial Natural Products Containing Fatty Acid Residues.” Angewandte Chemie International Edition<\/em>18 (2021<\/strong>): 10064-10072;<\/li>\n
- Mesiti, Francesco, et al<\/em>. “4-Oxoquinolines and monoamine oxidase: When tautomerism matters.” European Journal of Medicinal Chemistry<\/em> 213 (2021<\/strong>): 113183;<\/li>\n
- Cruz, Lu\u00eds, et al.<\/em> “Dendrimers as Color-Stabilizers of Pyranoanthocyanins: The Dye Concentration Governs the Host\u2013Guest Interaction Mechanisms.” ACS Applied Polymer Materials<\/em>3 (2021<\/strong>): 1457-1464;<\/li>\n
- Reis, Jo\u00e3o PA, et al.<\/em> “BrtB is an O-alkylating enzyme that generates fatty acid-bartoloside esters.” Nature communications<\/em>1 (2020<\/strong>): 1-9;<\/li>\n
- Reis, Ana, et al.<\/em> “Interaction of polyphenols with model membranes: Putative implications to mouthfeel perception.” Biochimica et Biophysica Acta (BBA)-Biomembranes <\/em>2 (2020<\/strong>): 183133;<\/li>\n
- Ara\u00fajo, Marco, et al.<\/em> “Coumarin-grafted blue-emitting fluorescent alginate as a potentially valuable tool for biomedical applications.” Journal of Materials Chemistry B<\/em>4 (2020<\/strong>): 813-825;<\/li>\n
- Fernandes, Ana, et al.<\/em> “Molecular binding between anthocyanins and pectic polysaccharides\u2013Unveiling the role of pectic polysaccharide\u2019s structure.” Food Hydrocolloids<\/em> 102 (2020<\/strong>): 105625;<\/li>\n
- Dias, Ricardo, et al.<\/em> “A multi-spectroscopic study on the interaction of food polyphenols with a bioactive gluten peptide: From chemistry to biological implications.” Food chemistry<\/em> 299 (2019<\/strong>): 125051.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
CEMUP \u2013 Centro de Materiais da Universidade do Porto Universidade do Porto Rua do Campo Alegre, 823 4150-180 Porto Portugal Tel: +351 220 408 250 Fax: +351 226 003 654 NMR Equipment Bruker Ascend 600 MHz Bruker Avance III 400 MHz Bruker Ascend III 400 MHz Unit Homepage UPorto – CEMUP Booking | Scheduling… Read More »Universidade do Porto – CEMUP<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":""},"_links":{"self":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784"}],"collection":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/comments?post=784"}],"version-history":[{"count":10,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784\/revisions"}],"predecessor-version":[{"id":3500,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784\/revisions\/3500"}],"wp:attachment":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/media?parent=784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Unit Homepage<\/h5>\n
UPorto – CEMUP<\/a><\/p>\n lrmn@cemup.up.pt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n CEMUP \u2013 Centro de Materiais da Universidade do Porto Universidade do Porto Rua do Campo Alegre, 823 4150-180 Porto Portugal Tel: +351 220 408 250 Fax: +351 226 003 654 NMR Equipment Bruker Ascend 600 MHz Bruker Avance III 400 MHz Bruker Ascend III 400 MHz Unit Homepage UPorto – CEMUP Booking | Scheduling… Read More »Universidade do Porto – CEMUP<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":""},"_links":{"self":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784"}],"collection":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/comments?post=784"}],"version-history":[{"count":10,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784\/revisions"}],"predecessor-version":[{"id":3500,"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/pages\/784\/revisions\/3500"}],"wp:attachment":[{"href":"https:\/\/ptnmr.web.ua.pt\/index.php\/wp-json\/wp\/v2\/media?parent=784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Booking | Scheduling<\/h5>\n
Main Research Topics<\/h4>\n
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Selected Publications<\/strong><\/h4>\n
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