Universidade de Coimbra - FCT - DQ

Main Research Topics

General Domains of Interest

• Organic Synthesis
• Metabolite proifiling
• Polymer characterization
• Biomaterials
• Protein - Ligand interactions
• Nanomaterials
• Peptide Structure

Specific Topics of Research

• Topic 1 : Structure and dynamics characterization of new compounds derived from chemical synthesis.
• Topic 2 : Tridimensional structure determination of peptide models in different chemical environments.
• Topic 3 : Characterization of in the terapeutic targets.
• Topic 4 : Screening of chemical libraries for bioactive compounds.
• Topic 5 : Diffusion as a tool to characterize large conformational changes in peptides, proteins and synthetic polymers.
• Topic 6 : Metabolite profiling in Diabetes.

Selected Publications

1. Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-Breast Cancer Properties, Maria I. L. Soares, Ana Filipa Brito, Mafalda Laranjo, José A. Paixão, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo Eur. J. Med. Chem.2013, i60, 254-262 [http://dx.doi.org/10.1016/j.ejmech.2012.11.036].

2. Barosa, C., Silva, C., Fagulha, A., Barros, L., Caldeira, M.M., Carvalheiro, M. and Jones, J.G. Sources of hepaticglycogen synthesis following a milk-containing breakfast meal in healthy subjects. 2012. Met. Clin & Exp. 61:250-254.

3. [4+2] Cycloadditions of 3-Tetrazolyl-1,2-diaza-1,3-butadienes: Synthesis of 3-Tetrazolyl-1,4,5,6 tetrahydropyridazines, Susana M. M. Lopes, Amadeu F. Brigas, Francisco Palacios, Américo Lemos, Teresa M. V.D. Pinho e Melo, Eur. J. Org. Chem. 2012, 2152-2160 [DOI: 10.1002/ejoc.201101826].

4. Diffusion Coefficients of Bolaform Alkane-1,nbis(trimethylammonium bromide) Surfactants, Ana C.F. Ribeiro, Cecília I.A.V. Santos, Dina B. Murtinho, Victor M.M. Lobo, Artur J. M. Valente, J. Chem. Thermodynamics, 2012, 50, 89-93 [http://dx.doi.org/10.1016/j.jct.2012.02.004].

5. Reversible Addition−Fragmentation Chain Transfer Polymerization of Vinyl Chloride, Carlos M. R. Abreu, Patrícia V. Mendonça, Arménio C. Serra, Jorge F. J. Coelho, Anatoliy V. Popov, Ganna Gryn’ova, Michelle L. Coote, and Tamaz Guliashvili, Macromolecules 2012, 45, 2200−2208 [http://pubs.acs.org/doi/pdfplus/10.1021/ma300064j].

6. Recent Developments in Oxidative Processes in Steroid Chemistry, Salvador, Jorge A. R.; Silvestre, Samuel M.; Moreira, Vania M., Curr. Org. Chem., 2012, 16, 1243-1276 [http://www.eurekaselect.com/97908/article].

7. Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate(MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives, Salvador, Jorge A. R.;Moreira, Vania M.; Pinto, Rui M. A.; Leal, Ana S; Paixao, Jose A., BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2012, 8, 164-169 [doi:10.3762/bjoc.8.17].

8. Systematic Study on Catalytic Synthesis of Unsaturated 2-ketocarboxamides: Palladium-Catalyzed Double Carbonylation of 1-iodocyclohexene, Rui M. B. Carrilho, Mariette M. Pereira, Attila Takács, László Kollár, Tetrahedron 68 (2012) 204, DOI: 10.1016/j.tet. 2011.10.065.

9. Separation and Atropisomer Isolation of ortho-halogenated Tetraarylporphyrins by HPLC. Full Characterization using 1D and 2D NMR, Carlos J.P. Monteiro, Mariette M. Pereira, Nuno P.F. Gonçalves, Carla G. Carvalho, Ângela Neves, Artur A. Abreu, Luis G. Arnaut, Artur M.S. Silva, J. Porphyrins & Phatalocyanines 16 (2012), 316, DOI: 10.1142/S1088424612500368.

10. Salvador J A R; Carvalho J F S; Neves M A C; Silvestre M S; Leitão A J; M. Silva M M C; Sá e Melo M L “Anticancer steroids: linking natural and semi-synthetic compounds” Nat. Prod. Rep. , 2012, DOI: 10.1039/C2NP20085F.

11. Ana S. Leal, Rui Wang, Jorge A. R. Salvador, Yongkui Jing, Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells, ChemMedChem 2012; 7: 1635–1646, DOI: 10.1002/cmdc.201200282

12. Carvalho JFS, Cruz Silva MM, Moreira JN, Simões S, Melo MLS. “Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in vitro evaluation and SAR” J. Med. Chem. 54, (18): 6375-6393 (2011). http://dx.doi.org/10.1021/jm200803d

13. Dąbrowski JM, Krzykawska M, Arnaut LG, Pereira MM, Monteiro CJ, Simões S, Urbańska K, Stochel G. “Tissue Uptake Study and Photodynamic Therapy of Melanoma-Bearing Mice with a Nontoxic, Effective Chlorin” Chem. Med. Chem. 6, (9): 1715-1726 (2011). http://dx.doi.org/10.1002/cmdc.201100186

14. Moreira VM, Salvador JA, Beja AM, Paixão JA. “The Reaction of Azoles with 17-Chloro-16-formylandrosta-5,16-dien-3β-yl-acetate: Synthesis and Structural Elucidation of Novel 16-Azolylmethylene-17 oxoandrostanes” Steroids 76, (6): 582–587 (2011). http://dx.doi.org/10.1016/j.steroids.2011.02.009

15. Pereira NAM, Fonseca SM, Serra AC, Pinho e Melo TMVD, Burrows HD. “Cycloaddition of meso- Tetra- and 5,15-Di- Arylporphyrins: Synthesis and Photophysical Characterization of Stable Chlorins and Bacteriochlorins” Eur. J. Org. Chem. 2011, (20-21): 3970-3979 (2011). http://dx.doi.org/10.1002/ejoc.201100465

16. Nunes CM, Reva I, Pinho e Melo TM, Fausto R, Šolomek T, Bally T. “The pyrolysis of isoxazole revisited: a new primary product and the pivotal role of the vinylnitrene. A lowtemperature matrix isolation and computational study” J.Am. Chem. Soc. 133, (46): 18911-18923 (2011). http://dx.doi.org/10.1021/ja207717k

17. Carvalho JFS, Cruz Silva MM, Sa e Melo ML. “Efficient trans-diaxial hydroxylation of Δ5-steroids” Tetrahedron 66,(13): 2455-2462 (2010). http://dx.doi.org/10.1016/j.tet. 2010.01.089

18. Nunes CM, Silva MR, Beja AM, Fausto R, Pinho e Melo TMVD “Cycloaddition of trifluoromethyl azafulvenium methides: synthesis of new trifluoromethylpyrroleannulated derivatives” Tetrahedron Letters 51 (2): 411-414 (2010). http://dx.doi.org/10.1016/j.tetlet.2009.11.033